Deregulated pyrimidine metabolism (PyMet) contributes to various tumorigenic features of cancer, including chemoresistance and epithelial-to-mesenchymal transition. However, cancer often encompasses ...

Researchers tested experimental PCAI compounds against pancreatic cancer cells and found they had powerful anticancer effects. One leading compound blocked more than 90% of cancer cell migration, ...

Interrupting one function of a protein that plays a key role in cell signaling could enable the development of new cancer treatments, according to a study led by Dr. Martin Taylor at the Warren Alpert ...

Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably ...

A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD Faculty of Medicine provides fundamental insights into cancer biology. Published in the renowned journal ...

Image Caption: Controversial effects of the STING pathway in colitis development. In colon cancer, the pathway shows a similarly complex profile. Activation of STING can stimulate immune defenses that ...

Cancer cells are remarkably good at adapting to stress. When treatments damage them, they often find new ways to survive, ...

MicroRNAs (miRNAs) play a very important role in the development of gastric cancer (GC). MiR-30a-5p Participates in the formation and progression of various cancers. However, the role and clinical ...

Dandelion root extract has shown remarkable potential in laboratory tests against colorectal cancer cells, triggering ...