In 1953, scientists pieced together a twisted molecule, and DNA finally had a shape

Scientists uncovered DNA's double helix structure in 1953. James Watson and Francis Crick proposed the model. It explained ...
Nature

PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation

PARP1 detection of DNA strand breaks allosterically leads to PARP1 synthesis of poly(ADP-ribose) modifications that signal DNA damage. HPF1 engages activated PARP1 to control modification site ...
Nature

Predicting the effect of binding molecules on the shape and mechanical properties of structured DNA assemblies

Rapid advances in structural DNA nanotechnology for precise programming of shape and properties of structural DNA assemblies 1,2,3 have presented broad applications with harnessing DNA-binding ligands ...