Pretrained language models have shown promise in analysing nucleotide sequences, yet a versatile model excelling across diverse tasks with a single pretrained weight set remains elusive. Here we ...

Small RNAs are more than just short sequences composed of A, C, G and U. They are integral constituents of complex gene regulatory pathways shaped by evolution. Although exceptions do exist, such as ...

National Cancer Institute researchers have developed a method called HORNET for characterizing 3D topological structures of large and flexible RNA molecules. Scientists used atomic force microscopy ...

Charles Darwin described evolution as "descent with modification." Genetic information in the form of DNA sequences is copied and passed down from one generation to the next. But this process must ...

Now, a pair of Scripps Research Institute scientists has taken a significant step toward answering that question. The scientists have synthesized for the first time RNA enzymes that can replicate ...

The original version of this story appeared in Quanta Magazine. For a molecule of RNA, the world is a dangerous place. Unlike DNA, which can persist for millions of years in its remarkably stable, ...

UC Vice President for Research Patrick Limbach is a key figure in the National Academies’ massive undertaking to sequence RNA in the next 15 years. A chemist who leads the University of Cincinnati’s ...

In 2020, Juan Alfonzo, a professor of molecular biology, cell biology and biochemistry, began a project out of “pure COVID boredom.” Now, that project may become the largest scientific undertaking ...