Scientific American

How CRISPR could target the body’s epigenome—the software that controls our genes

A handful of start-up firms are testing therapies that target specific epigenetic markers to treat everything from high ...
Nature

Why the temporal dimension matters in cellular signalling

Temporal encoding of signalling dynamics is not just widespread; it offers a fundamental information-theoretic advantage in cellular communication. Recent advances in channel capacity measurement and ...
Thorax

Performance of multivariable risk prediction algorithms in predicting COPD exacerbations: a population-based study

Introduction Efficient preventive management of acute exacerbation of chronic obstructive pulmonary disease (COPD) is ...
BMJ Open

Protocol for the economic evaluation of integrated longitudinal public health interventions in a cluster randomised controlled trial setting: the healthy life trajectories ...

Introduction In 2021, globally, cardiometabolic diseases (CMDs) accounted for 35% of the 1.73 billion disability-adjusted life years (DALYs) attributed to non-communicable diseases. The Healthy Life ...
Nature

Psychedelics reopen the social reward learning critical period

Reads were pseudoaligned to the mouse GENCODE vM25 (ref. 71) reference transcriptome using kallisto (v0.46.2) with 100 bootstrapped samples and 6 threads. Defaults were used for all other parameters.
Frontiers

Effective Delivery of Integrated Interventions in Early Childhood: Innovations in Evidence Use, Monitoring, Evaluation and Learning

Rigorous, integrated monitoring evaluation and learning (MEL) systems can support quality and scalable interventions to improve health and development. Early Child Development (ECD) provides an ...