aDepartment of Oncology, St Jude Children's Research Hospital and University of Tennessee Health Science Center, Memphis, TN, USA bDepartment of Pathology, St Jude Children's Research Hospital and ...

Figure 1: RNA-seq data uses short reads of mRNA which is free of intronic non-coding DNA. These reads must then be aligned back to the reference genome. Credit: Technology Networks. Early RNA-seq ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. Motivated by ...

Human pluripotent stem cells (hPSCs) are important tools in preclinical research and disease modeling. Valid results can only be obtained using thoroughly quality-controlled hPSCs, which includes ...

It has been estimated that the human genome contains more than 10 million nucleotide positions that have common (defined as >1%) variation between individuals in a population 1. The prevailing ...

Semaphorin 6D (SEMA6D), a member of the class 6 semaphorin family, is a membrane-associated protein that plays a key role in the development of cardiac and neural tissues. A growing body of evidence ...

Contributed by X. Sunney Xie, November 25, 2015 (sent for review November 21, 2015; reviewed by John Rasko and Kangpu Xu) One missing or wrong nucleotide out of six billion in a human genome can cause ...

Objective To review biomarker discovery studies using omics data for patient stratification which led to clinically validated FDA-cleared tests or laboratory developed tests, in order to identify ...

Fusarium head blight (FHB) incited by Fusarium graminearum Schwabe is a devastating disease of barley and other cereal crops worldwide. Fusarium head blight is associated with trichothecene mycotoxins ...

Intracranial aneurysms (IAs) are localized dilatations of intracranial arteries that are because of weaknesses of the endothelial layer. These dilations vary in size (small aneurysms, <5 mm; medium-to ...