Spatial transcriptomics platforms such as 10x Visium capture whole-transcriptome expression but at spot-level resolution where each measurement aggregates multiple cells. Existing computational ...

The heart and brain are among the earliest and most metabolically demanding organs in human development. Though historically studied in isolation, both ...

This project will generate computational tools to integrate high resolution spatial transcriptomic data with in-depth electroencephalogram (EEG) recordings to investigate how sleep architecture ...

The gut microbiome is not a mere spectator but an active player in colorectal cancer (CRC), driving tumor initiation and ...

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

Study: Common polyethylene microplastics may worsen fatty liver disease. In mice on high-fat diets, exposure doubled liver ...

Neurological disorders and neuro oncology impose a growing clinical and societal burden, while therapeutic development remains slow, costly, and uncertain.

People communicate with each other, sometimes face to face, sometimes with a text message or phone call. Cells also communicate with each other, sometimes by touching and sometimes by sending signals ...

Cellist is a computational method to perform cell segmentation on high-resolution spatial transcriptomics (ST) data, including sequncing-based (e.g. Stereo-seq and Seq-Scope) and imaging-based (e.g.

stLearn is designed to comprehensively analyse Spatial Transcriptomics (ST) data to investigate complex biological processes within an undissociated tissue. ST is emerging as the “next generation” of ...

1 Translational Gastroenterology And Liver Unit, University of Oxford, Oxford, United Kingdom 2 Centre for Computational Biology, Weatherall Institute of Molecular Medicine, University of Oxford, ...

1 Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China 2 Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China 3 ...