Crystal-design principle reveals how competing molecular forces control structure, color and phase transitions

Organic molecular crystals can respond to external stimuli such as heat, light, and mechanical force, making them attractive candidates for next-generation functional materials. However, predicting ...
PNAS

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Natural products provide the inspiration for most drugs, and marine natural products, in particular, are emerging as promising new therapeutics with new targets or mechanisms of action.
Frontiers

Strategy for Development of Site-Specific Ubiquitin Antibodies

Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent attachment of the small protein ubiquitin to a ...
C&EN

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

† Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K. ‡ Medicinal Chemistry, Department of Pharmacy and Pharmacology, ...