The Lancet

DNA methylation landscapes of HIV controllers: an epigenome-wide association study

aCentre for Individualised Infection Medicine (CiiM), A Joint Venture Between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany bTWINCORE, A ...
The Conversation

There are 750 unidentified human remains in Australia. Could your DNA help solve one of these cold cases?

Yesterday it was announced the Australian Federal Police (AFP) National DNA Program for Unidentified and Missing Persons used advanced DNA technology to assist South Australia Police resolve a 40-year ...
GitHub

An R package for hierarchical clustering with p-values

pvclust is an R package for assessing the uncertainty in hierarchical cluster analysis. For each cluster in hierarchical clustering, quantities called p-values are calculated via multiscale bootstrap ...
Frontiers

Design of Hydrogel Silk-Based Microarrays and Molecular Beacons for Reagentless Point-of-Care Diagnostics

We have developed a novel microarray system based on three technologies: 1) molecular beacons designed to interact with DNA targets at room temperature (25–27°C), 2) tridimensional silk-based ...
Frontiers

Advances and Trends in Omics Technology Development

• Can simultaneously detect the impact of several metabolites. • Does not directly translate into changes in protein activity due to restrictions to protein-metabolite binding; It is worth mentioning ...
Fierce Healthcare

Ancestry rolls out more advanced DNA testing to flag risk of heart disease, breast cancer

Ancestry moved into consumer genetic health testing in October 2019 and is now relaunching its AncrestryHealth service with next-generation sequencing technology ...
eLife

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

The CRISPR-Cas9 targeted nuclease technology allows the insertion of genetic modifications with single base-pair precision. The preference of mammalian cells to repair Cas9-induced DNA double-strand ...
GitHub

Integrated analysis of Cross-platform MicroArray and Pathway data

Have you ever tried to integrate omics data from different biological layers? InCroMAP is a powerful, easy-to-use high-level cross-platform microarray dataset analysis tool. It provides several ...
Nature

Using airbrushes to pattern reagents for microarrays and paper-fluidic devices

The high cost of medical diagnostics and the importance of detecting infectious diseases in a timely, cost-effective manner have increased the importance of point-of-care (POC) testing. Lateral flow ...
The Lancet

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

bClinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany cDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany ...
C&EN

Bilayer-Spanning DNA Nanopores with Voltage-Switching between Open and Closed State

Membrane-spanning nanopores from folded DNA are a recent example of biomimetic man-made nanostructures that can open up applications in biosensing, drug delivery, and nanofluidics. In this report, we ...