Copy number variations (CNVs) constitute an important class of variation in the human genome and the interpretation of their pathogenicity considering different frequencies across populations is still ...
Discrepancies between preclinical tests and clinical results raise serious concerns about the appropriateness of the current methodologies. In particular, cell biology approaches neglect fundamental ...
Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, California 90048, United States Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, ...
The wealth of high-throughput data has opened up new opportunities to analyze and describe biological processes at higher resolution, ultimately leading to a significant acceleration of scientific ...
Copyright: © 2021 The Authors. Published by Elsevier B.V. Pancreatic ductal adenocarcinoma (PDAC) is characterized by an important heterogeneity, reflected by ...
GO:0001533 Cornified envelope 3.8E-12 10.45 FLG, HRNR, KRT2, LCE1A, LCE1C, LCE2D, SPRR2F GO:0031424 Keratinization 7.7E-12 3.93 CASP14, FLG, HRNR, KRT2, KRT73, LCE1A ...
Here, we show that expression of key circadian clock genes in the skin is altered by acute inflammation in mice treated topically with the immune activator imiquimod and by chronic inflammation in ...
Progression of asymptomatic carotid artery stenosis (ACAS) in patients with >50% luminal narrowing is considered a potential risk factor for ischemic stroke; however, subclinical molecular biomarkers ...
B7-H3 (CD276), part of the B7 superfamily of immune checkpoint molecules, has been shown to have an immunomodulatory role. Its regulation, receptor and mechanism of action remain unclear. B7-H3 ...
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