NOTE: December 2024 main software development has moved to PanGEMMA! GEMMA is a software toolkit for fast application of linear mixed models (LMMs) and related models to genome-wide association ...

Probabilistic reasoning is central to many theories of human cognition, yet its foundations are often presented through abstract mathematical formalisms disconnected from the logic of belief and ...

Introduction Causal methods have been adopted and adapted across health disciplines, particularly for the analysis of single studies. However, the sample sizes necessary to best inform decision-making ...

jDepartment of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada kDepartment of Family and Community Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada ...

aDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China bDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, ...

In analyses of longitudinal records, it is standard practice to attribute systematic differences across units to heterogeneity in unobserved characteristics. In this paper, we show that such ...

External comparator (EC) studies are increasingly being used to generate evidence that supports the evaluation of emerging pharmacological treatments for regulatory and health technology assessment ...

This report proposes a stepwise process covering the range of considerations to systematically consider key choices for study design and data analysis for non-interventional studies with the central ...

The Breakthrough Devices Program of the US Food and Drug Administration has accelerated the development and evaluation of medical devices for patients with heart failure. One such device is the ...

In the article that accompanies this editorial, Lu et al 5 conducted a systematic review on the use of instrumental variable (IV) methods in oncology comparative effectiveness research. The main ...