A developer reverse-engineering Anthropic's Claude Code binary discovered on June 30, 2026, that the tool had been silently encoding hidden signals into its AI system prompts for at least three months ...
The precise, temporal order of gene expression during development is critical to ensure proper lineage commitment, cell fate determination, and ultimately, organogenesis. Epigenetic regulation of ...
Gastric cancer (GC) is a prevalent malignant tumor globally, posing a significant threat to human health. The histone code reader Spindlin1 (SPIN1) has been implicated in tumorigenesis and tumor ...
Lactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule. We briefly summarize ...
The multiple-domain protein ZMYND8 is well known as a chromatin reader that recognizes methylated, acetylated, and/or mutated histones. Here we report that ZMYND8 is overexpressed in human ccRCC, and ...
Histone H3Q5ser and H3K4me3 can coexist as a dual modification pattern to regulate active gene transcription. However, the molecular impact of H3Q5ser on H3K4me3 recognition and catalysis remains ...
The histone modification writer Prdm9 has been shown to deposit H3K4me3 and H3K36me3 at future double-strand break (DSB) sites during the very early stages of meiosis, but the reader of these marks ...
Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, OX3 7DQ Oxford, U.K. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, OX3 7FZ ...
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