STATOpinion

CDC leadership continues to try to manufacture a scientific debate on vaccines where none exists

CDC leadership continues to try manufacture a scientific debate on vaccines where none exists, writes Ben Lopman.

Toward experiment-guided AlphaFold: Researchers overcome AI tool's single-conformation limitation

The AI-based program AlphaFold predicts a protein's 3D structure with remarkable accuracy. However, it tends to reduce heterogeneous structures to a single dominant conformation, or shape, and ...
C&EN

A Novel Method for Development and Validation of the Degradation Products Analysis of N-Carbamylglutamate with UHPLC by Using Design of Experiment Approach

The administration of this test is an essential element in the process of method development, as it guarantees the capability of the LC equipment and the established technique to deliver reliable ...
C&EN

Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances

This review presents the Analytical Quality by Design (AQbD) concept, an extension of Quality by Design (QbD), which was introduced in 2004 by the U.S. Food and Drug Administration (FDA) and approved ...