Abstract: Sequence alignment using evolutionary profiles is a commonly employed tool when investigating a protein. Many profile-profile scoring functions have been developed for use in such alignments ...

Nobel Prize in Chemistry 2024 co-laureate US chemist and computer scientist John Jumper gives his Nobel Prize lecture in Aula Magna, Stockholm University, Sweden, on December 8, 2024. Pontus ...

Abstract: Sequence alignment is a crucial tool in biological research. Alignment quality is typically assessed using scores, but these do not guarantee optimality. Estimating the optimal alignment ...

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WitChi is an analysis and pruning tool designed to evaluate and reduce compositional bias in multiple sequence alignments (MSAs). It utilizes statistical methods, permutation tests, and parallel ...

Aligning short-read sequences is the foundational step to most genomic and transcriptomic analyses, but not all tools perform equally, and choosing among the growing body of available tools can be ...

TAPER is a tool that looks for errors in small species-specific stretches of the multiple sequence alignments. TAPER uses a two-dimensional outlier detection algorithm that seeks to find what parts of ...

Department of Mathematics, Jinan University, Guangzhou, China. With the rapid growth in biological data, how to get more information from these big data is a challenge for scientists. For this purpose ...

This article describes several features in the MAFFT online service for multiple sequence alignment (MSA). As a result of recent advances in sequencing technologies, huge numbers of biological ...