By combining CRISPR knock-in with small peptide tags, researchers can study proteins in their native cellular context, ...

Abstract: Learning from imbalanced data occurs very frequently in functional genomic applications. One positive example to thousands of negative instances is common in scientific applications.

This study presents an advance in efforts to use histone post-translational modification (PTM) data to model gene expression and predict epigenetic editing activity. Such models are broadly useful to ...

The T32 grant provides full-time research training support for post-candidacy predoctoral learners pursuing mentored clinical and translational research or clinical and translational science who are ...

There are many typs of protein modification, which are mostly catalyzed by enzymes that recognize specific target sequences in proteins. These modifications regulate protein folding by targeting ...

The first thing Promise Bio CEO Ronel Veksler wants you to know about the biotech company he co-founded is that it’s not another AI drug discovery company. Instead, he’s looking to bring precision ...

Imagine riding a bike. Now imagine riding a bike with an enormous beach ball stuck on your handlebars. That "modification" might change your experience quite a bit. In our cells, molecules called ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Nature increases the functional diversity of the proteome through posttranslational modifications (PTMs); a process that involves the proteolytic processing or catalytic attachment of diverse ...

Lamins are the ancient type V intermediate filament proteins contributing to diverse biological functions, such as the maintenance of nuclear morphology, stabilization of chromatin architecture, ...

The sequencing of the first human genome in 2003 marked a major milestone in molecular biology. In the years since, it has become apparent that the human proteome – the collection of proteins that are ...