The Lancet

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis

aState Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated ...
GitHub

Pathway Enrichment-Guided Activity Study of Alternative Splicing (PEGASAS)

Note that the installation process will only automatically check and install python package dependencies. If the R packages required for PEGASAS are missing, they can ...
GitHub

GALS-Fold: Geometry-Aware Long-Short RNA Inverse Folding with Linear Scaling

Set up a python environment by following the installation instructions below. The experiments were conducted with Python 3.10.19 and CUDA 12.1 on RTX 4090 GPUs, with consistent results also observed ...
ahajournals.org

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

Monocytes are a critical innate immune system cell type that serves homeostatic and immunoregulatory functions. They have been identified historically by the cell surface expression of CD14 and CD16.
PNAS

Computational inference of eIF4F complex function and structure in human cancers

To understand the importance of eIF4F components, we employed computational methods on large public datasets to investigate the impact of positive selection on eIF4F dysregulation in cancer. By ...
Frontiers

Single-Cell RNA Sequencing Unravels Distinct Tumor Microenvironment of Different Components of Lung Adenocarcinoma Featured as Mixed Ground-Glass Opacity

Lung adenocarcinoma featured as mixed ground-glass opacity (mGGO) doubled its volume half of the time in comparison with that featured as pure ground-glass opacity (pGGO). The mechanisms underlying ...