Genome editing lets scientists rewrite DNA, the instruction manual inside every living cell, with a precision that was unthinkable a generation ago. Technologies such as CRISPR have made this almost ...

Heart failure with preserved ejection fraction (HFpEF) is a poorly understood, multisystem disease with high morbidity and mortality. To improve understanding of its pathobiology, we analyzed ...

MDANSE is a Python package designed for analysing molecular dynamics (MD) trajectories. One of its functions is calculating the expected results of neutron scattering experiments. The results can be ...

Retrospective Analysis of BRCA-Altered Uterine Sarcoma Treated With Poly(ADP-ribose) Polymerase Inhibitors Chondrosarcomas are rare cancers of cartilage with limited systemic therapy options. To ...

Applied Bioinformatics, Department of Computer Science, University of Tübingen, Tübingen 72074, Germany Institute for Bioinformatics and Medical Informatics, University of Tübingen, Tübingen 72074, ...

MEREDITH identified a broader range of treatment options (median 4) compared with MTB experts (median 2). These options included therapies on the basis of preclinical data and combination treatments, ...

With the release of more and more AlphaFold (Jumper et al., 2021) or RoseTTAFold (Baek et al., 2021) predicted structures and experimentally determined structures, it is important to be able to do ...

In silico assessment of protein receptor interactions with small ligands is now part of the standard pipeline for drug discovery, and numerous tools and protocols have been developed for this purpose.

What does SARS-CoV-2, the virus that causes COVID-19, look like? This simple question does not have a simple answer. SARS-CoV-2 is very small, and seeing it requires specialized scientific techniques.

The molecular mechanisms mediating postnatal loss of cardiac regeneration in mammals are not fully understood. We aimed to provide an integrated resource of mRNA, protein, and metabolite changes in ...