adj.P.Val thresholds: NTM (FDR < 0.05), TB (FDR < 0.001). Full gene lists are provided in Supplementary Tables. Signaling receptor activity (27.1% of genes); Cytokine binding capacity (14.6%). Table 3 ...
Sitting above the physical layer is the link layer, which is responsible for scanning, advertising, creating, and maintaining links or connections between devices. The link layer also manages ...
An 8-year-old girl presented with psychomotor and visual deterioration, which began at the age of 5. She was the first and only child of a healthy non-consanguineous Chinese couple. She was born ...
Catalysis Engineering, Chemical Engineering Department, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands Chemical Engineering Research Center, School of Chemical ...
The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a ...
Short linear motifs (SLiMs) located in disordered regions of multidomain proteins are important for the organization of protein–protein interaction networks. By dynamic association with their binding ...
Heterobifunctional molecules that recruit E3 ubiquitin ligases, such as cereblon, for targeted protein degradation represent an emerging pharmacological strategy. A major unanswered question is how ...
Mycobacterium tuberculosis (Mtb), the causative agent of the disease tuberculosis, grows in macrophages, cells that normally kill bacteria. Recent work has defined a macrophage pathway called ...
Without a vaccine or cost-effective antivirals against hepatitis C virus (HCV) there is a need to understand better the molecular mechanisms underlying the establishment of productive HCV infection ...
The pathogenesis of colistin induced nephrotoxicity is poorly understood. Currently there are no effective therapeutic or prophylactic agents available. This study was aimed to determine the mechanism ...
Recognition of injured mitochondria for degradation by macroautophagy is essential for cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner mitochondrial membrane ...
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